You can also find our work on Google Scholar and Research Gate.

​In Preparation
Goli, P, Kocarek, TA, and Kassotis, CD. Sex and physiology-specific metabolism disrupting chemical responses in human pre-adipocytes. Co-author review prior to publication. 

Bérubé, R, Murray, BR, Korzeniewski, SJ, and Kassotis, CD. Investigating a complex mixture of PPARg-activating chemicals on metabolic health outcomes in human mesenchymal stem cells and developmentally exposed zebrafish. ​Final writing and editing.   
​

Submitted/Under Review

Bérubé, R, LeFauve, MK, Khalaf, A, Aminioroomi, D, and Kassotis, CD. Effects of organic and inorganic contaminants and their mixtures on metabolic health and gene expression in developmentally exposed zebrafish. ​Under review. Pre-printed here. 

​
In Press / Published (53)

Bérubé, R, Murray, BR, Kocarek, TA, and Kassotis, CD. Nonylphenol and cetyl alcohol polyethoxylates disrupt thyroid hormone receptor signaling to promote metabolism disrupting effects. ​Endocrinology. 2024; in press. Journal link.  

​Geueke, B, Parkinson, LV, Groh, KJ, Kassotis, CD, Maffini, MV, Martin, OV, Zimmermann, L, Scheringer, M, and Muncke, J. Evidence for widespread human exposure to food contact chemicals. Journal of Exposure Science & Environmental Epidemiology. 2024; In press. Journal link.

Siegel, KR, Murray, BR, Gearhart, J, and Kassotis, CD. In vitro endocrine and cardiometabolic toxicity of artificial turf materials. Environmental Toxicology & Pharmacology. 2024; in press. Journal Link. 
​
Siegel, KR, Bérubé, R, Day, M, Heldman, S, Daley, C, Murray, BR, Hecht, R, Caron-Beaudoin, E, and Kassotis, CD. Evidence for reproductive health effects following exposures to unconventional oil and gas chemical mixtures. Reproduction. 2024; In press. Journal link.  

Chiang, Y-TT and Kassotis, CD. Molecular assessment of pro-adipogenic effects for common-use contraceptives and their mixtures. Endocrinology. 2024; 165(6), bqae050. Journal Link.

Vom Saal, FS, Antoniou, M, Belcher, SM, Bergman, A, Bhandari, RK, Birnbaum, LS, Cohen, A, Collins, TJ, Demeneix, B, Fine, AM, Flaws, JA, Gayrard, V, Goodson III, WH, Gore, AC, Heindel, JJ, Hunt, PA, Iguchi, T, Kassotis, CD, Kortenkamp, A, Mesnage, R, Muncke, J, Myers, JP, Nadal, A, Newbold, RR, Padmanabhan, V, Palanza, P, Pamla, Z, Parmiagiani, S, Patrick, L, Prins, GS, Rosenfeld, CS, Skaekkebaek, NE, Sonnenschein, C, Soto, AM, Swam, SH, Taylor, JA, Toutain, P-L, von Hippel, FA, Welshons, WV, Zalko, D, and Zoeller, RT. The Conflict between Regulatory Agencies over the 20,000-Fold Lowering of the Tolerable Daily Intake (TDI) for Bisphenol A (BPA) by the European Food Safety Authority (EFSA). Environmental Health Perspectives. 2024; In press. Journal Link. 

Overdahl, KE, Kassotis, CD, Hoffman, H, Getzinger, G, Phillips, AL, Hammel, SC, Stapleton, HM, and Ferguson, PL. Characterizing azobenzene disperse dyes and related compounds in house dust and their correlations with other organic contaminant classes. Environmental Pollution. 2023; 337, 122491. Journal Link.

Duh-Leong, C, Maffini, M, Kassotis, CD, Vandenberg, LN, and Trasande, L. Regulation of endocrine disrupting chemicals to minimize their impact on health. Nature Reviews Endocrinology. 2023. In press. Journal Link.

Kassotis, CD, and Phillips, AL. Complex Mixtures and Multiple Stressors: Evaluating Combined Chemical Exposures and Cumulative Toxicity. Toxics. 2023; 11(6), 487. Journal Link.

Bérubé, R, LeFauve, MK, Heldman, S, Chiang, Y-TT, Birbeck, JA, Westrick, J, Hoffman, K, and Kassotis, CD. Adipogenic and Endocrine Disrupting Mixture Effects of Organic and Inorganic Pollutant Mixtures. Science of the Total Environment. 2023; 876, 162587. Journal Link.

LeFauve, M, Berube, R, Heldman, S, Chiang, Y-T, and Kassotis, CD. Cetyl Alcohol Polyethoxylates Disrupt Metabolic Health in Developmentally Exposed Zebrafish. Metabolites. 2023; 13(3), 359. Journal Link.

Trasande, L, and Kassotis, CD. The pediatrician's role in protecting children from environmental exposures. Pediatric Clinics of North America. ​2022; 70(1): 137-150. Journal Link. 

Yang, Z, Roth, K, Ding, J, Kassotis, CD, Mor, G, and Petriello, MC. Exposure to a mixture of per- and polyfluoroalkyl substances modulates pulmonary expression of ACE2 and circulating hormones and cytokines. Toxicology and Applied Pharmacology. ​2022. Journal Link. 

​Geueke, B, Groh, KJ, Maffini, MV, Martin, OV, Boucher, J, Chiang, Y-T, Gwosdz, F, Jieh, P, Kassotis, CD, Łańska, P, Myers, P, Odermatt, A, Parkinson, LV, Schreier, VN, Srebny, V, Zimmermann, L, Scheringer, M, and Muncke, J. Systematic evidence on migrating and extractable food contact chemicals: Most chemicals detected in food contact materials are not listed for use. Critical Reviews in Food Science and Nutrition. 2022. Journal Link.

Filer, D, Hoffman, K, Sargis, RM, Trasande, L, and Kassotis, CD. On the Utility of ToxCast-Based Predictive Models to Evaluate Potential Metabolic Disruption by Environmental Chemicals. ​Environmental Health Perspectives. 2022; 130(5). Journal Link.

Lustig, RH, Collier, D, Kassotis, CD, Roepke, TA, Kim, MJ, Blanc, E, Barouki, R, Bansal, A, Cave, MC, Chatterjee, S, Choudhury, M, Gilbertson, M, Howard, S, Lagadic-Gossmann, D, Lind, L, Tomlinson, CR, Vondracek, J, and Heindel, JJ. Obesity I: Overview and Molecular and Biochemical Mechanisms. Biochemical Pharmacology. 2022. 199: 115012. Journal link. 

Heindel, JJ, Agay-Shay, K, Arrebola, JP, Audouze, K, Babin, PJ, Barouki, R, Bansal, A, Birnbaum, LS, Blanc, E, Cave, MC, Chatterjee, S, Chevalier, N, Choudhury, M, Collier, D, Connolly, L, Coumou, X, Garruti, G, Gilbertson, M, Howard, S, Hoepner, LA, Holloway, AC, Howell III, G, Kassotis, CD, Kay, MK, Kim, MJ, Lagadic-Gossmann, D, Langouet, S, Legrand, A, Li, Z, Le Mentec, H, Lind, L, Lind, PL, Lustig, RH, Martin-Chouly, C, Kos, VM, Podechard, N, Roepke, TA, Sargis, RM, Starling, A, Tomlinson, CR, Touma, C, Vondracek, J, vom Saal, F, and Blumberg, B. Obesity II: Establishing the Causal Link Between Chemical Exposures and Obesity. Biochemical Pharmacology. 2022; 199: 115015. Journal link. 

​Kassotis, CD, Vom Saal, FS, Babin, PJ, Lagadic-Gossmann, D, Le Mentec, H, Blumberg, B, Mohajer, N, Legrand, A, Kos, VM, Martin-Chouly, C, Podechard, N, Langouët, S, Touma, C, Barouki, R, Kim, MJ, Audouze, K, Choudhury, M, Shree, N, Bansal, A, Howard, S, and Heindel, JJ. Obesity III: Obesogen Assays: Limitations, Strengths, and New Directions. Biochemical Pharmacology. 2022; 199: 115014. Journal link. 

Kassotis, CD, LeFauve, M, Chiang, Y-T, Knuth, M, and Kullman, SM. Nonylphenol Ethoxylates Exacerbate Adipose Deposition in Developmentally Exposed Zebrafish. Toxics. 2022; 10, 99. Journal Link. 

Herkert, NJ, Kassotis, CD, Zhang, S, Han, Y, Pulikkal, VF, Sun, M, Ferguson, PL, and Stapleton, HM. Characterization of per- and polyfluorinated alkyl substances present in commercial anti-fog products and their in vitro adipogenic activity. Environmental Science & Technology. 2022; 56: 1162-1173. Journal Link. 

Kassotis, CD, Hoffman, K, Kim, SM, Schlezinger, JJ, Bovolin, P, Cottone, E, Saraceni, A, Scandiffio, R, Ermler, S, Legler, J, Atlas, E, Leingartner, K, Pu, Y, Veiga-Lopez, A, Völker, J, Mesmar, F, Bondesson, M, Fenton, S, Chappell, V, and Stapleton, HM. Reproducibility of Adipogenic Responses to Metabolic Disrupting Chemicals in the 3T3-L1 Pre-adipocyte Model System: An Interlaboratory Study. Toxicology. 2021. Journal Link.

Kassotis, CD and Trasande, L. Endocrine Disruptor Global Policy. Invited book chapter for: Advances in Pharmacology, volume 92. 2021. In press.
​
​​​​​​​Kassotis, CD, Phillips, AL, Hoffman, K, Zhang, S, Webster, TF, and Stapleton, HM. Characterization of Adipogenic, PPARg, and TRb Activities in House Dust Extracts and Their Associations with Organic Contaminants. Science of the Total Environment. 2020. Journal Link.

Kassotis, CD, Hoffman, K, Hammel, SC, Herkert, NJ, Kullman, SW, Sosa, JA, and Stapleton, HM. Thyroid Receptor Antagonism of Chemicals Extracted from Personal Silicone Wristbands within a Papillary Thyroid Cancer Pilot Study. Environmental Science & Technology. 2020. Journal Link.

Kassotis, CD, Harkness, JS, Vo, PH, Vu, DC, Hoffman, K, Lin, C-H, Cinnamon, KM, Cornelius-Green, JN, Vengosh, A, Lin, C-H, Tillitt, DE, Kruse, RL, McElroy, JA, and Nagel, SC. Endocrine Disrupting Activities and Geochemistry of Water Resources Associated with Unconventional Oil and Gas Activity. ​Science of the Total Environment. Journal Link.

Kassotis, CD, Vandenberg, LN, Demeneix, B, Slama, R, and Trasande, L. Endocrine Disrupting Chemicals: Economic, Regulatory, and Policy Implications. ​Lancet Diabetes & Endocrinology. 2020; 8(8): 719-730. Journal Link.

Jane Muncke, Anna-Maria Andersson, Thomas Backhaus, Justin M. Boucher, Bethanie Carney Almroth, Arturo Castillo Castillo, Jonathan Chevrier, Barbara A. Demeneix, Jorge A. Emmanuel, Jean-Baptiste Fini, David Gee, Birgit Geueke, Ksenia Groh, Jerrold J. Heindel, Jane Houlihan, Christopher D. Kassotis, Carol F. Kwiatkowski, Lisa Y. Lefferts, Maricel V. Maffini, Olwenn V. Martin, John Peterson Myers, Angel Nadal, Cristina Nerin, Katherine E. Pelch, Seth Rojello Fernández, Robert M. Sargis, Ana M. Soto, Leonardo Trasande, Laura N. Vandenberg, Martin Wagner, Changqing Wu, R. Thomas Zoeller, and Martin Scheringer. Impacts of food contact chemicals on human health: a consensus statement. Environmental Health. 2020; 19: article 25. Journal Link.

Nagel, SC, Kassotis, CD, Vandenberg, LN, Lawrence, BP, Robert, J, and Balise, VD. Developmental exposure to a mixture of unconventional oil and gas chemicals: A review of effects on adult health, behavior, and disease. Molecular & Cellular Endocrinology. 2020; 513: 110722. Journal Link.

​McElroy, JA, Kassotis, CD, and Nagel, SC. In our backyard: Beliefs about fracking, science, and health by community members. ​New Solutions. 2020; 30(1): 42-51. Journal Link.
​
Balise, VD, Cornelius-Green, JN, Parmenter, B, Baxter, S, Kassotis, CD, Rector, RS, Thyfault, JP, Palanza, P, Ruiz, D, Sargis, R, and Nagel, SC. Developmental Exposure to a Mixture of Unconventional Oil and Gas Chemicals Increased Risk-Taking Behavior, Activity and Energy Expenditure in Aged Female Mice After a Metabolic Challenge. Frontiers in Endocrinology. 2019; 10(460): 1-13. Journal Link.

Balise, VD, Cornelius-Green, JN, Kassotis, CD, Rector, RS, Thyfault, JP, and Nagel, SC. Preconceptional, Gestational, and Lactational Exposure to an Unconventional Oil and Gas Chemical Mixture Alters Energy Expenditure in Adult Female Mice. Frontiers in Endocrinology. 2019; 10(323): 1-10. Journal Link.

​Kassotis, CD, Kollitz, EM, Hoffman, K, Lorenzo, A, Hammel, S, and Stapleton, HM. Thyroid Receptor Antagonism as a Contributory Mechanism for Environmental Mixture Induced Adipogenesis in 3T3-L1 Cells. ​Science of the Total Environment. 2019; 666: 431-444. Journal Link.

Kassotis, CD and Stapleton, HM. Endocrine-Mediated Mechanisms of Metabolic Disruption and New Approaches to Examine the Public Health Threat. Frontiers in Endocrinology. 2019; 10(460): 1-22. Journal Link.

Kollitz, EM, Kassotis, CD, Hoffman, K, Ferguson, PL, Sosa, JA, and Stapleton, HM. Chemical Mixtures Isolated From House Dust Disrupt Thyroid Receptor beta (TRb) Signaling. Environmental Science & Technology. 2018; 52(20): 11857-11864. Journal Link.

​Kassotis, CD, Nagel, SC, and Stapleton, HM. Unconventional Oil and Gas Chemicals and Wastewater-Impacted Water Samples Promote Adipogenesis via PPARγ-Dependent and Independent Mechanisms in 3T3-L1 Cells. ​Science of the Total Environment. 2018; 640-641: 1601-1610. Journal Link.

Kassotis, CD, Vu, DC, Vo, PH, Lin, C-H, Cornelius-Green, JN, Patton, S, and Nagel, SC. Endocrine Disrupting Activities and Organic Contaminants in Wyoming Groundwater Associated with Unconventional Oil and Gas Operations. ​Archives of Environmental Contamination and Toxicology. 2018; 75(2): 247-258. Journal Link.

Boule, L, Chapman, T, Hillman, S, Georas, S, Kassotis, CD, Balise, VD, Nagel, SC, and Lawrence, BP. Developmental exposure to chemicals associated with unconventional oil and gas extraction alters CD4+ T cell populations in multiple immune responses. Toxicological Sciences. 2018; 163(2): 639-654. Journal Link.

Sapouckey, SS, Kassotis, CD, Nagel, SC, and Vandenberg, LN. Prenatal Exposure to Unconventional Oil and Gas Operation Chemical Mixtures Altered Mammary Gland Development in Adult Female Mice. Endocrinology. 2018; 159(3): 1277-1289. Journal Link.

Luz, AL, Kassotis, CD, Stapleton, HM, and Meyer, JN. The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and not PPARγ activation, in 3T3-L1 cells. Toxicology. 2018; 393: 150-159. ​Journal Link.

Kassotis, CD, Kollitz, EM, Ferguson, PL, and Stapleton, HM. Ethoxylated Surfactants Promote Adipogenesis in 3T3-L1 Cells. ​Toxicological Sciences. 2018; 162(1): 124-136. Journal Link.

Kassotis, CD, Hoffman, K, and Stapleton, HM. Characterization of Adipogenic Activity of Indoor House Dust Extracts and Semi-Volatile Indoor Contaminants in 3T3-L1 Cells. ​Environmental Science & Technology. 2017; 51(15): 8735-8745. Journal Link.

Kassotis, CD, Masse, L, Kim, S, Schlezinger, JJ, Webster, TF, and Stapleton, HM. Characterization of Adipogenic Chemicals in Three Different Cell Culture Systems: Implications for Reproducibility Based on Cell Source and Handling​. ​Scientific Reports. 2017; 7, 42104. Journal Link.

Kassotis, CD, Bromfield, JJ, Klemp, KC, Meng, C-X, Wolfe, A, Zoeller, RT, Balise, VD, Isiguzo, CJ, Tillitt, DE, and Nagel, SC. Adverse Reproductive and Developmental Health Outcomes Following Prenatal Exposure to a Hydraulic Fracturing Chemical Mixture in Female C57Bl/6 Mice. Endocrinology. 2016; 157(9): 3469-3481. Journal Link.

Balise, VD, Meng, C-X, Cornelius-Green, J, Kassotis, CD, Kennedy, R, and Nagel, SC. A systematic review of the association between oil and natural gas extraction processes and human reproduction. Fertility & Sterility. 2016; 106(4): 795-819. Journal Link.
​
Wylie, S, Schultz, K, Thomas, D, Kassotis, CD, and Nagel, SC. Inspiring Collaboration: The Legacy of Theo Colborn's Trans-Disciplinary Research on Fracking. New Solutions. 2016; 26(3): 360-388. ​Journal Link.

Kassotis, CD, Iwanowicz, L, Akob, DM, Cozzarelli, IM, Mumford, A, Orem, WH, and Nagel, SC. Endocrine Disrupting Activities of Surface Water Associated with a West Virginia Oil and Gas Industry Wastewater Disposal Site. Science of the Total Environment. 2016; 557-558: 901-910. Journal Link.

Kassotis, CD, Klemp, KC, Vu, DC, Lin, C-H, Drobnis, EZ, Balise, VD, Isiguzo, CJ, Williams, MA, Tillitt, DE, and Nagel, SC. Endocrine Disrupting Activity of Hydraulic Fracturing Chemicals and Adverse Health Outcomes Following Prenatal Exposure in Male Mice. Endocrinology. 2015; 156(12): 4458-4473. Journal Link.

Kassotis, CD, Tillitt, DE, Lin, C-H, McElroy, JA, and Nagel, SC. Endocrine Disrupting Chemicals and Oil and Natural Gas Operations: Recommendations to Assess Complex Environmental Mixtures. Environmental Health Perspectives. 2015; 124(3): 256-264. Journal Link.

Heindel, JJ, vom Saal, FS, Blumberg, B, Bovolin, P, Calamandrei, G, Ceresini, G, Cohn, BA, Fabbri, E, Gioiosa, L, Kassotis, CD, Legler, J, La Merrill, M, Rizzir, L, Machtinger, R, Mantovani, A, Mendez, MA, Montanini, L, Molteni, L, Nagel, SC, Parmigiani, S, Panzica, G, Paterlini, S, Pomatto, V, Ruzzin, J, Sartor, G, Schug, TT, Street, ME, Suvorov, A, Volpi, R, Zoeller, RT, Palanza, P. Parma Consensus Statement on Metabolic Disruptors. Environmental Health. 2015; 14(54): 1-7. Journal Link.

Kassotis, CD, Alvarez, DA, Taylor, JA, vom Saal, FS, Nagel, SC, and Tillitt, DE. Characterization of Missouri Surface Waters near Point Sources of Pollution Reveals Potential Novel Route of Exposure for Bisphenol A and Wastewater Hormonal Activity Pattern. Science of the Total Environment. 2015; 524-525: 384-393. Journal Link.

Bhandari, R, Deem, SL, Holliday, DK, Jandegian, CM, Kassotis, CD, Nagel, SC, Tillitt, DE, Vom Saal, FS, and Rosenfeld, CS. Effects of the Environmental Estrogenic Contaminants Bisphenol A and 17α-Ethinylestradiol on Sexual Development and Adult Behaviors in Aquatic Wildlife Species. General and Comparative Endocrinology. 2015; 214: 195-219. Journal Link.

Webb, E, Bushkin-Bedient, S, Cheng, A, Kassotis, CD, Balise, V, and Nagel SC. Developmental and Reproductive Effects of Chemicals associated with Unconvential Oil and Natural Gas Operations. Reviews on Environmental Health. 2014; 29(4): 308-318. Journal Link.

Kassotis, CD, Tillitt, DE, Davis, JW, Hormann, AM, and Nagel, SC. Estrogen and Androgen Receptor Activity of Natural Gas Drilling Chemicals and Surface and Ground Water in a Drilling-Dense Region. Endocrinology. 2014; 155(3): 897-907. Journal Link