Current Grant-funded Projects
Lateral view of a zebrafish developmentally-exposed to nonylphenol ethoxylate and aged to 30 days. Nile Red stain fluorescently labels the fat cells throughout the fish.
|
|
Metabolic Disruption Potential of Organic and Inorganic Contaminant Mixtures
Currently funded through a P30 Center Pilot award through the Center for Urban Responses to Environmental Stressors (CURES) via NIEHS. This project aims to explore the potential hormone receptor activation/
inhibition and metabolic disruption of organic and inorganic pollutant mixtures relevant to Michigan environmental health. Our goals are to: 1) Characterize concentrations of inorganic pollutants in household dust samples and examine associations with organic pollutants/bioactivities. 2) Assess adipocyte development and receptor disruption following exposure to select organic/inorganic contaminants and mixtures. 3) Assess adipocyte/adipose tissue development following exposure to select organic/inorganic contaminants and mixtures in zebrafish. |
Visualization of differentiated 3T3-L1 pre-adipocytes. Green = Nile Red lipid stain; blue = Hoechst DNA stain (cell number).
|
Other Projects/Broad Research Interests
Metabolic Disruption by Environmental
|
Visualization of differentiated 3T3-L1 pre-adipocytes. Yellow = Nile Red lipid stain; blue = Hoechst DNA stain (cell number).
|
A natural gas well in Garfield County, Colorado, an extremely dense unconventional oil/natural gas production region.
|
|
Assessing Health Risks from Exposure to
|
Humans and animals are regularly exposed to complex mixtures of hundreds/thousands of chemicals, most of them not regulated, with uncertain health effects.
|