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The Kassotis Lab

is open at Wayne State University! We joined the Institute of Environmental Health Sciences (lab home in the Integrative Biosciences Center - IBio), with a co-appointment in the Department of Pharmacology. 

Our lab will be focused on understanding endocrine disrupting chemicals (EDCs) and mixtures, and their potential impacts on human/animal health - with a particular focus on metabolic health (e.g. obesity, etc.). 

My research uses a mixture of cell culture mechanism assays, coupled with zebrafish and mouse models, to characterize molecular mechanisms underpinning potential impacts of EDCs on human and animal health.

Research
Lab News and Updates
July 2022
Notice of award for a three-year EPA STAR grant to evaluate toxicological mixture models through testing of a set of laboratory mixtures of increasing complexity on adipogenesis using human mesenchymal stem cells and adiposity using the zebrafish model. 

June 2022
Brooklynn Murray has joined the group as our new Research Assistant! 
Jake Holloway has joined the group as an undergraduate student researcher! 

Our lab attended the 2022 Gordon Research Conference on Environmental Endocrine Disruptors in Sunday River, Maine, and presented data from four ongoing projects in the lab!

May 2022
Latest lab publication is out now in Environmental Health Perspectives!: On the Utility of ToxCast-Based Predictive Models to Evaluate Potential Metabolic Disruption by Environmental Chemicals. 

Another collaborative effort published on profiling all the chemicals used in food contact packaging!: Systematic evidence on migrating and extractable food contact chemicals: Most chemicals detected in food contact materials are not listed for use.

April 2022
Latest set of publications are out now in Biochemical Pharmacology that are authored by several dozen experts in metabolic health, obesity, and chemical obesogens. Articles discuss state of the evidence for molecular mechanisms promoting obesity (I), causal evidence for obesogens (II), and assays available and emerging to measure obesogens (III).

Obesity I: Overview and molecular and biochemical mechanisms.
Obesity II: Establishing causal links between chemical exposures and obesity.
Obesity III: Obesogen assays: Limitations, strengths, and new directions.  

News Coverage: Environmental Health News
Webinar on topic: Collaborative on Health & the Environment

February 2022
Latest lab publication is out now in Toxics (first direct K99/R00 publication!): Nonylphenol polyethoxylates enhance adipose deposition in developmentally exposed zebrafish. 
Tweets by @cdkassotis

Please feel free to contact me with questions and comments!


Twitter

@cdkassotis

Email

cdkassotis@wayne.edu
“You cannot get through a single day without having an impact on the world around you. What you do makes a difference, and you have to decide what kind of difference you want to make.” — Jane Goodall