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The Kassotis Lab

is open at Wayne State University! We joined the Institute of Environmental Health Sciences (lab home in the Integrative Biosciences Center - IBio), with a co-appointment in the Department of Pharmacology. 

Our lab will be focused on understanding endocrine disrupting chemicals (EDCs) and mixtures, and their potential impacts on human/animal health - with a particular focus on metabolic health (e.g. obesity, etc.). 

My research uses a mixture of cell culture mechanism assays, coupled with zebrafish and mouse models, to characterize molecular mechanisms underpinning potential impacts of EDCs on human and animal health.

Research
Lab News and Updates
October 2025
One new publication out from our lab this month!

PhD student Samantha Heldman published a cell-based assessment of liquid crystal monomers (chemicals used in LCD panels) and their mixtures for endocrine and metabolism disrupting effects, in Endocrinology: 
"Liquid Crystal Monomers and their Mixtures Alter Nuclear Receptor Signaling and Promote Adipogenesis In Vitro". 


A new Research Assistant / Lab Manager has joined the lab - Madeline English! She joins us from an MS in Toxicology program in Texas and we're excited to have her expertise join the team!

Kassotis Lab attended the Michigan Society of Toxicology meeting this year with 6! One undergrad (poster), one research assistant (poster), one PhD student (oral presentation), and another PhD student and research assistant attending and not presenting. 

Kyle Siegel was awarded first place platform presentation at MISOT for his talk on endocrine and metabolic disrupting effects of metal mixtures relevant to oil and gas. 

September 2025
Our postdoc, Dr. Roxanne Bérubé, has departed the laboratory and is opening her own research lab at McGill University in the Department of Pharmacology and Therapeutics. Her position starts in October!

We published two new co-author publications this month:

1) "The Food Contact Chemicals Health effect matrix (FCChelix): protocol for a systematic evidence map", in Evidence-Based Toxicology. 

2) "Zearalenone at environmental levels promoted ER- positive breast cancer cell lines through the hedgehog pathway", in Ecotoxicology & Environmental Safety. 

July 2025
Two publications out from our lab this month!

1) Postdoc Roxanne Bérubé published a mixture developmental toxicity assessment in zebrafish in Environmental Toxicology & Chemistry:
"Effects of organic and inorganic contaminants and their mixtures on metabolic health and gene expression in developmentally exposed zebrafish". 


2) Praneeth Goli's MS thesis research has been published in Toxicology and Applied Pharmacology:
"Metabolism disrupting effects in human pre-adipocytes: Influence of donor sex and body composition". 


June 2025
Our lab was awarded an NIEHS R01 award to continue our study of polyethoxylated surfactants, ubiquitous environmental contaminants used widely in hard surface cleaners and detergents. WSU link here.

April 2025
Dayton McGrail officially joined the lab as our next PhD student! She will work on finishing her PET rotation project and then transition to dissertation research from there. 

March 2025
Our latest co-author lab publication, a collaboration with the Sadagurski Lab, has been published in Science of the Total Environment:
"Integrative multi-omics analysis of metabolic dysregulation induced by occupational benzene exposure in mice". 


The Kassotis Lab attended the Society of Toxicology meeting in Orlando, Florida! We had two talks and two posters from our lab this year - along with several awards (Kyle and Samantha)!

February 2025
The Kassotis Lab celebrated another great year with axe throwing at a local Detroit spot!

January 2025
Dayton McGrail presented her rotation project work on PET plastic product endocrine activity at the WSU Graduate Student Research Presentation Day!

Please feel free to contact me with questions and comments!


Twitter

@cdkassotis

Email

[email protected]
“You cannot get through a single day without having an impact on the world around you. What you do makes a difference, and you have to decide what kind of difference you want to make.” — Jane Goodall